Identification and verification of inflammatory biomarkers for primary Sj ögren’s syndrome

ConclusionFour inflammation-associated biomarkers (LY6E, EIF2AK2, IL15, and CXCL10) were explored, and the underlying regulatory mechanisms and targeted drugs associated with these biomarkers were preliminarily investigated according to a series of bioinformatics methods based on the online datasets of pSS, which provided a reference for understanding the pathogenesis of pSS.Key Points•Inflammation-associated biomarkers (LY6E, EIF2AK2, IL15, and CXCL10) were firstly identified in Sj ögren’s syndrome based on LASSO and SVM-RFE analyses.•CXCL10, EIF2AK2 and LY6E were prominently positively correlated with immature B cells, while IL15 were significantly negatively correlated with memory B cells in Sj ögren’s syndrome.•LY6E, EIF2AK2, IL15, and CXCL10 were significantly more highly expressed in clinical Sj ögren’s syndrome samples compared to healthy control samples, which was consistent with the analysis results of the GEO database.•LY6E, EIF2AK2, IL15, and CXCL10 might be used as the biomarkers for the treatment and diagnosis of Sj ögren’s syndrome.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research