IL23R G149R promotes IL-23 unresponsiveness in human memory Th17 cells

Leprosy, an ancient infectious dermatosis, is caused by the obligate intracellular pathogen Mycobacterium leprae, which has a predilection for the skin and peripheral nerves, this disease can lead to severe deformity and social stigma (Britton and Lockwood, 2004). Advances have been made in understanding the genetic basis of the disease, which is inherited as a complex trait resulting from gene-gene and gene-environment interactions (Elder et al., 2010). Dozens of susceptibility genes have been found to be associated with leprosy in the past several years through genome-wide association studies, genome-wide meta-analysis and high-throughput sequencing, thus deepening understanding of the pathogenesis of leprosy.

Source: Journal of Investigative Dermatology - March 26, 2024 Category: Dermatology Authors: Chuan Wang, Zhenzhen Wang, Tingting Liu, Zihao Mi, Wenchao Li, Yuan Zhang, Na Wang, Fuzhong Xue, Qiji Liu, Hong Liu, Furen Zhang Tags: Letters to the Editor Source Type: research