The IRE1 α-endonuclease plays a dual role in regulating the XBP1/miRNA-34a axis and PD-1 expression within Natural Killer cells in Hodgkin Lymphoma

CONCLUSION: The IRE1α-endonuclease emerges as a key player, simultaneously regulating the XBP1s/microRNA-34a-5p/PD-1 axis in NK-cells, a process disrupted in HL. Targeting the IRE1α-pathway holds promise as a therapeutic strategy to optimise NK-cell functions in Hodgkin Lymphoma treatments.PMID:38479365 | DOI:10.1159/000536044

Source: Acta Haematologica - March 13, 2024 Category: Hematology Authors: Karolina Bednarska Gayathri Thillaiyampalam Sally Mujaj Jamie Nourse Jay Gunawardana Muhammed B Sabdia Soi C Law Anna Pilaar Qingyan Cui Lilia M de Long Frank Vari Maher K Gandhi Alexandre S Cristino Source Type: research