Curative criteria for endoscopic treatment of colorectal cancer

Best Pract Res Clin Gastroenterol. 2024 Feb;68:101883. doi: 10.1016/j.bpg.2024.101883. Epub 2024 Jan 25.ABSTRACTAs endoscopic treatment enables en bloc resection of T1 colorectal cancers, the risk of recurrence, often assimilated to the risk of lymph node metastases, must be assessed in order to offer patients an additional treatment if this risk is deemed significant. The curative criteria currently used by most guidelines are depth of invasion <1 mm, well or moderately differentiated tumour, absence of lympho-vascular invasion, absence of significant budding and tumour-free resection margins. However, these factors must be assessed by qualified pathologists, as they are difficult to evaluate. Moreover, the combination of these factors leads to unnecessary surgery in over 80 % of patients whose tumours are classified as high risk. Refinement of current criteria and research into new tumour and immunological markers are needed to better predict the actual risk of our patients.PMID:38522881 | DOI:10.1016/j.bpg.2024.101883
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research