The PIEZO1/miR-155-5p/GDF6/SMAD2/3 signaling axis is involved in inducing the occurrence and progression of osteoarthritis under excessive mechanical stress

CONCLUSION: GDF6 overexpression or miR-155-5p inhibition could attenuate overloading-induced chondrocyte senescence and OA through the PIEZO1-miR-155-5p-GDF6-SMAD2/3 signaling pathway. Our study provides a new therapeutic target for the treatment of overloading-induced OA.PMID:38508350 | DOI:10.1016/j.cellsig.2024.111142

Source: Cellular Signalling - March 20, 2024 Category: Cytology Authors: Chaoren Qin Yan Feng Zhaowei Yin Changjiang Wang Rui Yin Yang Li Kai Chen Tianqi Tao Kaibin Zhang Yiqiu Jiang Jianchao Gui Source Type: research