How Can We Interpret the Unexpected Results in Two Pilot Trials Comparing Thiamine to Placebo after Cardiac Arrest?

Patients managed in the ICU following cardiac arrest suffer from multiple complications, including brain ischaemia resulting from reperfusion injury, circulatory failure and the risk of multiorgan failure [1]. To date, management has been largely supportive, with common ICU interventions aimed at normalising circulation, preventing secondary insults and employing neuroprognostication through a delayed multimodal approach [2]. A common characteristic of these patients is early lactatemia, which relates to whole-body ischaemia occurring during cardiac arrest.
Source: Resuscitation - Category: Emergency Medicine Authors: Tags: Editorial Source Type: research