Progress on synthesis and structure-activity relationships of lamellarins over the past decade

Eur J Med Chem. 2024 Mar 6;269:116294. doi: 10.1016/j.ejmech.2024.116294. Online ahead of print.ABSTRACTLamellarins are polyaromatic alkaloids isolated from marine organisms, including mollusks, tunicates, and sponges. Currently, over 60 structurally distinct natural lamellarins have been reported, and most of them exhibit promising biological activities, such as topoisomerase inhibition, mitochondrial function inhibition, multidrug resistance reversing, and anti-HIV activity. There has also been a significant progress on the synthetic study of lamellarins which has been regularly updated by numerous medicinal chemists as well. This review provides a detailed summary of the synthesis, pharmacology, and structural modification of lamellarins over the past decades.PMID:38508119 | DOI:10.1016/j.ejmech.2024.116294
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research