Dopamine promotes Klebsiella quasivariicola proliferation and inflammatory response in the presence of macrophages

ConclusionsOur findings suggest that dopamine may be one of the potential risk factors associated with K. quasivariicola infection. This empirical insight provides solid references for clinical precision medicine. Furthermore, an in vitro model of microbes-drugs-host immune cells for inhibitor screening was proposed to more accurately replicate the complex in vivo environment. This fundamental work had contributed to the present understanding of the crosstalk between pathogen, dopamine and host immune cells.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research