Alternative splicing decouples local from global PRC2 activity

The mechanisms driving PRC2 subtype assembly and dimerization in  vivo are not yet understood. Arecco, Mocavini, et al. report an alternative splicing variant of SUZ12 (SUZ12-S) that promotes PRC2.1 dimerization, resulting in increased H3K27me3 deposition at target genes. SUZ12-S is necessary and sufficient for Polycomb gene repression in embryonic stem cells.

Source: Molecular Cell - March 6, 2024 Category: Cytology Authors: Niccol ò Arecco, Ivano Mocavini, Enrique Blanco, Cecilia Ballaré, Elina Libman, Sophie Bonnal, Manuel Irimia, Luciano Di Croce Tags: Article Source Type: research