Novel TFG mutation causes autosomal-dominant spastic paraplegia and defects in autophagy

Conclusions
Our findings suggest that autophagy impairment may serve as a common pathomechanism among different clinical phenotypes caused by TFG mutations. Consequently, targeting autophagy may facilitate the development of a uniform treatment for TFG-related neurological disorders.

Source: Journal of Medical Genetics - March 21, 2024 Category: Genetics & Stem Cells Authors: Xu, L., Wang, Y., Wang, W., Zhang, R., Zhao, D., Yun, Y., Liu, F., Zhao, Y., Yan, C., Lin, P. Tags: Neurogenetics Source Type: research