Association of Catechol-O-Methyltransferase (COMT) val158met genetic polymorphism and outcomes following sacral neuromodulation or onabotulinumtoxina in women with urgency irinary incontinence

The mechanism of action of neuromodulation (percutaneous tibial nerve stimulation [PTNS] or sacral neuromodulation [SNM]) for the treatment of urgency urinary incontinence and/or fecal incontinence is poorly understood. Previously we showed an association between the catechol-O-methyltransferase (COMT) Val158Met (rs4680) single nucleotide polymorphism (SNP) and PTNS response in women with fecal incontinence. We hypothesized that COMT may also be associated with response to SNM.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Source Type: research