PLCE1 enhances mitochondrial dysfunction to promote GSDME-mediated pyroptosis in doxorubicin-induced cardiotoxicity

CONCLUSIONS: We discovered firstly that PLCE1 inhibition protected cardiomyocytes from DOX-induced pyroptotic injury and promoted cardiac function. This information offers a theoretical basis for promising therapy.PMID:38499110 | DOI:10.1016/j.bcp.2024.116142

Source: Biochemical Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Authors: Maierhaba Tuersuntuoheti Fei Peng Juexing Li Lei Zhou Hailan Gao Hui Gong Source Type: research