The role of polyethylenimine-functionalized gold nanoclusters carrying plasmid CMTM5 in impeding the malignant progression of prostate cancer cells by promoting EGFR endocytosis

In conclusion, the PEI-AuNCs nano-delivery system exhibits good biocompatibility and efficaciously conveys pCMTM5 to PCa cells. Crucially, pCMTM5 does not directly interact with EGFR, and CMTM5 governs the malignant progression of PC3 cells by promoting EGFR endocytosis.PMID:38295104 | DOI:10.4149/neo_2024_231018N544

Source: Neoplasma - January 31, 2024 Category: Cancer & Oncology Authors: Linjin Li Chengpeng Li Feilong Miao Wu Chen Xianghui Kong Ruxian Ye Rui Feng Source Type: research