Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease

CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | DOI:10.1503/jpn.230066

Source: Journal of Psychiatry and Neuroscience - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research