TCR Signals Controlling Adaptive  Immunity against Toxoplasma and Cancer

Adv Exp Med Biol. 2024;1444:177-193. doi: 10.1007/978-981-99-9781-7_12.ABSTRACTT cells play a crucial role in adaptive immunity by recognizing and eliminating foreign pathogens and abnormal cells such as cancer cells. T cell receptor (TCR), which is expressed on the surface of T cells, recognizes and binds to specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). This activation process leads to the proliferation and differentiation of T cells, allowing them to carry out their specific immune response functions. This chapter outlines the TCR signaling pathways that are common to different T cell subsets, as well as the recently elucidated TCR signaling pathway specific to CD8+ T cells and its role in controlling anti-Toxoplasma and anti-tumor immunity.PMID:38467980 | DOI:10.1007/978-981-99-9781-7_12
Source: Advances in Experimental Medicine and Biology - Category: Research Authors: Source Type: research