Single nucleotide variants in nuclear pore complex disassembly pathway associated with poor survival in osteosarcoma

Discussion:Overall survival is significantly worse in patients whose tumors show aberrations in the NPCD pathway. Moreover, this difference in survival is not driven by MYC-overexpression, suggesting a novel mechanism for some aggressive osteosarcomas. These findings add light to the evolving understanding of the drivers of osteosarcoma and may aid in the search for new treatments based on patient-specific genetic data.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research