Sensitive B-cell receptor repertoire analysis shows repopulation correlates with clinical response to rituximab in rheumatoid arthritis

CONCLUSION: Our findings indicate that rather than BCR-depletion it is repopulation with unmutated BCRs, possibly from naïve B cells, which induces remission. This suggests that (pre-existing) differences in B-cell turnover between patients explain the interindividual differences in early clinical effect.PMID:38493208 | DOI:10.1186/s13075-024-03297-7

Source: Cell Research - March 17, 2024 Category: Cytology Authors: Sabrina Pollastro Anne Musters Giulia Balzaretti Ilse Niewold Barbera van Schaik Signe H ässler Catharina M Verhoef Marc Pallardy Antoine van Kampen Xavier Mariette Niek de Vries ABIRISK Consortium Source Type: research