Cross-sectional and Longitudinal Associations Between Metal Mixtures and Serum C3, C4: Result from the Manganese ‑exposed Workers Healthy Cohort

Biol Trace Elem Res. 2024 Mar 16. doi: 10.1007/s12011-024-04143-2. Online ahead of print.ABSTRACTExposure to metal mixtures compromises the immune system, with the complement system connecting innate and adaptive immunity. Herein, we sought to explore the relationships between blood cell metal mixtures and the third and fourth components of serum complement (C3, C4). A total of 538 participants were recruited in November 2017, and 289 participants were followed up in November 2021. We conducted a cross-sectional analysis at baseline and a longitudinal analysis over 4 years. Least Absolute Shrinkage and Selection Operator (LASSO) was employed to identify the primary metals related to serum C3, C4; generalized linear model (GLM) was further used to evaluate the cross-sectional associations of the selected metals and serum C3, C4. Furthermore, participants were categorized into three groups according to the percentage change in metal concentrations over 4 years. GLM was performed to assess the associations between changes in metal concentrations and changes in serum C3, C4 levels. At baseline, each 1-unit increase in log10-transformed in magnesium, manganese, copper, rubidium, and lead was significantly associated with a change in serum C3 of 0.226 (95% CI: 0.146, 0.307), 0.055 (95% CI: 0.022, 0.088), 0.113 (95% CI: 0.019, 0.206), - 0.173 (95% CI: - 0.262, - 0.083), and - 0.020 (95% CI: - 0.039, - 0.001), respectively. Longitudinally, decreased copper concentrations were negativ...

Source: Biological Trace Element Research - March 16, 2024 Category: Biology Authors: Sencai Lin Junxiu He Yinghua Zhou Yu Bao Xiuming Feng Hong Cheng Haiqing Cai Sihan Hu Lin Wang Yuan Zheng Mengdi Zhang Qinghua Fan Shifeng Wen Yuanxin Lin Chaoqun Liu Xing Chen Fei Wang Xiaoting Ge Xiaobo Yang Source Type: research