Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis

ConclusionThese findings collectively elucidate the critical role of FBXO9 in regulating V-ATPase assembly and provide a molecular basis for FBXO9 ’s function in inhibiting lung cancer metastasis. This highlights the potential therapeutic opportunities of FBXO9 supplementation.

http://link.springer.com/10.1186/s40164-024-00497-4

Source: Experimental Hematology and Oncology - March 14, 2024 Category: Cancer & Oncology Source Type: research