Undescribed (2-7')-neolignans and polyoxygenated cyclohexene glycosides from the aerial parts of Piper mutabile C. DC. and their inhibitory effects on nitric oxide production
Fitoterapia. 2024 Mar 11:105903. doi: 10.1016/j.fitote.2024.105903. Online ahead of print.ABSTRACTA phytochemical study of the aerial parts of Piper mutabile C. DC. revealed seven undescribed compounds [two (2-7')-neolignans and five polyoxygenated cyclohexene glycosides] and six known propenylcatechol derivatives. The chemical structures of the isolated compounds were elucidated by extensive HR-ESI-MS and NMR analyses, as well as comparison with the literature. The absolute configurations of the (2-7')-neolignans were confirmed by GIAO 13C NMR calculations with a sorted training set strategy and TD-DFT calculation ECD spectra. The (2-7')-neolignans and polyoxygenated cyclohexene glycosides are unusual in natural sources. Undescribed neolignans 1 and 2 inhibited NO production in RAW 264.7 cells, with respective IC50 values of 14.4 and 9.5 μM.PMID:38479620 | DOI:10.1016/j.fitote.2024.105903
Source: Fitoterapia - Category: Biochemistry Authors: Phan Van Kiem Nguyen Xuan Nhiem Nguyen Huy Hoang Ngo Anh Bang Pham Hai Yen Do Thi Trang Duong Thi Dung Nguyen Thi Cuc Phan Thi Thanh Huong Bui Huu Tai Source Type: research