Dysregulation in CD39/CD73 Axis May Trigger the Upsurge of the Immune Suppressive Agent Adenosine in OSA Patients

CONCLUSION: Our study reveals a hypoxia-mediated alteration of the CD39/CD73 axis in OSA patients, which could trigger ADO upregulation, thus potentially contributing to the immune suppressive environment and ultimately facilitating tumor development and progression. Therefore, our data highlights the need for new longitudinal studies evaluating CD39 and/or CD73 as potential cancer-risk prognostic biomarkers in OSA patients.PMID:38485582 | DOI:10.1016/j.arbres.2024.02.013

Source: Archivos de Bronconeumologia - March 14, 2024 Category: Respiratory Medicine Authors: Elena D íaz-García Aldara Garc ía-Sánchez Enrique Alfaro Cristina L ópez-Fernández Eva Ma ñas Raquel Casitas Sara Vega Irene Cano-Pumarega Francisco Garc ía-Río Carolina Cubillos-Zapata Source Type: research