Pulmonary lipofibroblasts in adults and alveolar regeneration in emphysema

Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00145-1. doi: 10.1016/j.rmr.2024.02.015. Online ahead of print.ABSTRACTLipofibroblasts form a sub-population of fibroblasts located in the mesenchymal alveolar stem cell niche. They show close proximity with alveolar epithelial type 2 cells and play a key role in alveolar development and lung homeostasis. Their role in various diseases such as acute respiratory distress syndrome, pulmonary fibrosis and emphysema is progressively better understood. Through the activation of signaling pathways such as PPARg lipofibroblasts may help to induce endogenous alveolar regeneration.PMID:38461092 | DOI:10.1016/j.rmr.2024.02.015
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Authors: Source Type: research