Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis

CONCLUSIONS: These data demonstrated that hemodynamic stress induced a protective rewiring of sphingolipid metabolism, favoring S1P over ceramide. NOGO-B deletion sustained the rewiring of sphingolipid metabolism toward S1P protecting EC from activation under hemodynamic stress and refraining coronary atherosclerosis. These findings also set forth the foundation for sphingolipid-based therapeutics to limit atheroprogression.PMID:38456287 | DOI:10.1161/CIRCRESAHA.123.323826

Source: Circulation Research - March 8, 2024 Category: Cardiology Authors: Onorina Laura Manzo Jasmine Nour Linda Sasset Alice Marino Luisa Rubinelli Sailesh Palikhe Martina Smimmo Yang Hu Maria Rosaria Bucci Alain Borczuk Olivier Elemento Julie K Freed Giuseppe Danilo Norata Annarita Di Lorenzo Source Type: research