New diarylcyclopentenone enantiomers and biphenyl derivatives from the fungus Talaromyces adpressus

Bioorg Chem. 2024 Mar 9;146:107280. doi: 10.1016/j.bioorg.2024.107280. Online ahead of print.ABSTRACTTen new compounds, including three pairs of diarylcyclopentenone enantiomers (±) talaromycesins A-C (1-3) and four biphenyl derivatives talaromycesins D-G (4-7), along with four known compounds (8-11), were isolated from the fungus Talaromyces adpressus. Their structures were determined by analyses of extensive NMR spectroscopic and HRESIMS data, and their absolute configurations were elucidated by the dimolybdenum tetraacetate [Mo2(AcO)4]-induced ECD spectra, X-ray crystallographic studies, and ECD calculations. These new compounds were evaluated for their immunosuppressive activities for the first time, and compound 7 probably exerted liver-protective and anti-inflammatory effects on Con A-induced AIH by decreasing the levels of inflammatory cytokines, modulating immune homeostasis, and decreasing hepatocyte apoptosis, which may become a potential drug for the treatment of autoimmune diseases.PMID:38479131 | DOI:10.1016/j.bioorg.2024.107280
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research