Twelve Month Follow Up on MARSH: A Pilot, First in Human Study of Autologous IFN-gamma Stimulated Mesenchymal Stromal Cells for Treatment of Radiation-induced Xerostomia

There are no existing effective treatments for radiation-induced xerostomia (RIX), a common side effect of head and neck radiation. Mesenchymal stromal cells (MSCs) exhibit regenerative effects in multiple tissues and may represent an effective cell therapy for the treatment of RIX. Here we present the updated primary safety and secondary efficacy endpoints of a first-in-human pilot study of IFN γ-stimulated autologous bone marrow- derived MSCs [MSC(M)] for the treatment of RIX.

Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: G.C. Blitzer, T. Glazer, S. Gustafson, A. Burr, R. Pena, R. Mattison, O. Ganz, R. Meyers, M. Weiss, K. McDowell, K.P. Nickel, R.J. Chappell, N. Pulia, J. Gallipeau, R.J. Kimple Tags: 189 Source Type: research