Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium

In conclusion, these results suggest that ER stress primes TSLP which is then enhanced further upon TLR3 activation, which may induce severe asthma exacerbations. Targeting ER stress using pharmacological interventions may provide novel therapeutics for severe uncontrolled asthma.PMID:38469627 | DOI:10.1152/ajplung.00378.2023
Source: Am J Physiol Lung Ce... - Category: Respiratory Medicine Authors: Source Type: research