Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function

CONCLUSIONS: Thrombocytopenia immune programs monocytes in a manner that may lead to immune dysfunction in the context of sepsis. This is the first demonstration that sterile, endogenous cell interactions between resting platelets and monocytes regulate monocyte metabolism and pathogen responses, demonstrating platelets to be immune rheostats in both health and disease.REGISTRATION: URL: https://www.biorxiv.org/content/10.1101/2023.05.10.540214v1.full; Unique identifier: XXX.PMID:38456277 | DOI:10.1161/CIRCRESAHA.123.323662

Source: Circulation Research - March 8, 2024 Category: Cardiology Authors: Chen Li Sara K Ture Benjamin Nieves-Lopez Sara K Blick-Nitko Preeti Maurya Alison C Livada Tyler J Stahl Minsoo Kim Anthony P Pietropaoli Craig N Morrell Source Type: research