CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletion

Conclusion
Together, the findings imply costimulatory molecules as key regulators of cytotoxicity-driven pathology in systemic autoimmune disease, yielding CD7 as a novel target for selective depletion of pathogenic cells.

Source: Annals of the Rheumatic Diseases - March 12, 2024 Category: Rheumatology Authors: Papadimitriou, T. I., Singh, P., van Caam, A., Walgreen, B., Gorris, M. A. J., Vitters, E. L., van Ingen, I. L., Koenders, M. I., Smeets, R. L., Vonk, M., de Vries, J. M., van der Kraan, P. M., van Oosterhout, Y., Huynen, M. A., Koenen, H. J. P. M., Thurl Tags: Open access, ARD, Systemic sclerosis Source Type: research