Emicizumab Promotes Factor Xa Generation on Endothelial Cells

CONCLUSIONS: Emicizumab promotes FXa generation on the surface of endothelial cells, which is markedly enhanced in the presence of FEIBA®. These findings demonstrate a potential mechanism for the thrombotic complications seen with the combined use of emicizumab and FEIBA®.PMID:38460838 | DOI:10.1016/j.jtha.2024.02.017

Source: Thrombosis and Haemostasis - March 9, 2024 Category: Hematology Authors: Ammon M Fager Patrick Ellsworth Nigel S Key Dougald M Monroe Maureane Hoffman Source Type: research