Tumor-infiltrating lymphocytes refine outcomes in triple-negative breast cancer treated with anthracycline-free neoadjuvant chemotherapy

CONCLUSIONS: sTILs density was independent predictor of OS beyond clinicopathologic features and pathologic response in TNBC patients treated with anthracycline-free CbD chemotherapy. Notably, sTILs density stratified outcomes beyond TNM stage and pathologic response. These findings highlight role of sTILs in patient selection/stratification for neo/adjuvant escalation and de-escalation strategies.PMID:38466643 | DOI:10.1158/1078-0432.CCR-24-0106

Source: Clinical Genitourinary Cancer - March 11, 2024 Category: Cancer & Oncology Authors: Miguel Mart ín Rachel Yoder Roberto Salgado Maria Del Monte-Mill án Enrique L Alvarez Isabel Echavarr ía Joshua M Staley Anne P O'Dea Lauren E Nye Shane R Stecklein Coralia Bueno Mui ño Yolanda Jerez-Gilarranz Mar ía Cebollero Oscar Bueno Jose Ángel Source Type: research