Neutron capture enhances dose and reduces cancer cell viability in and out of beam during helium and carbon ion therapy

Neutron Capture Enhanced Particle Therapy (NCEPT) is a proposed augmentation of charged particle therapy which exploits thermal neutrons generated internally, within the treatment volume via nuclear fragmentation, to deliver a biochemically targeted radiation dose to cancer cells. This work is the first experimental demonstration of NCEPT, performed using both carbon and helium ion beams with two different targeted neutron capture agents (NCAs).

Source: International Journal of Radiation Oncology * Biology * Physics - March 11, 2024 Category: Radiology Authors: Nicholas Howell, Ryan J. Middleton, Frederic Sierro, Naomi A. Wyatt, Andrew Chacon, Benjamin H. Fraser, Keith R. Bambery, Elle Livio, Christopher Dobie, Joseph J. Bevitt, Justin Davies, Anthony Dosseto, Daniel R. Franklin, Ulf Garbe, Susanna Guatelli, Ryo Tags: Biology Contribution Source Type: research