In  Vivo Synaptic Density in Early Schizophrenia: Are There No Differences or Are They Too Small to Detect?

Schizophrenia is a chronic psychiatric disorder with a prevalence of approximately 1% worldwide and incurs a high annual cost of approximately $343 billion. It continues to be one of the leading causes of years lived with disability worldwide. While the precise etiology and pathophysiology of the disorder remains unknown, an array of neuropathological abnormalities have been reported in schizophrenia, including altered neuronal density, decreased neuron size, altered cortical cytoarchitecture, and reduced cortical dendritic spine density.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research