Immunobiology and treatment of cutaneous T-cell lymphoma

Expert Rev Clin Immunol. 2024 Mar 7:1-12. doi: 10.1080/1744666X.2024.2326035. Online ahead of print.ABSTRACTINTRODUCTION: Primary cutaneous T cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas derived from skin-homing T cells. These include mycosis fungoides and its leukemic variant Sezary syndrome, as well as the CD30+ lymphoproliferative disorders.AREAS COVERED: In this review, we provide a summary of the current literature on CTCL, with a focus on the immunopathogenesis and treatment of mycosis fungoides and Sezary syndrome.EXPERT OPINION: Recent advances in immunology have provided new insights into the biology of malignant T cells. This in turn has led to the development of new therapies that modulate the immune system to facilitate tumor clearance or target specific aspects of tumor biology.PMID:38450476 | DOI:10.1080/1744666X.2024.2326035
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research