TET3-mediated DNA demethylation modification activates SHP2 expression to promote endometrial cancer progression through the EGFR/ERK pathway

CONCLUSION: TET3 promoted the DNA demethylation modification in the SHP2 promoter and activated SHP2, thus activating the EGFR/ERK pathway and leading to EC progression.PMID:38456588 | DOI:10.3802/jgo.2024.35.e64

Source: Journal of Gynecologic Oncology - March 8, 2024 Category: OBGYN Authors: Fen Xue Lifen Liu Xueqiang Tao Weipei Zhu Source Type: research