Per- and polyfluoroalkyl substances inhibit human and rat 17 β-hydroxysteroid dehydrogenase 1: Quantitative structure-activity relationship and molecular docking analysis

In conclusion, PFAS exhibit inhibitory effects on human and rat 17β-HSD1 depending on factors such as carbon chain length, degree of fluorination, and the presence of carboxylic acid or sulfonic acid groups, with a notable V-shaped shift observed at C11.PMID:38452703 | DOI:10.1016/j.ecoenv.2024.116173

Source: Ecotoxicology and Environmental Safety - March 7, 2024 Category: Environmental Health Authors: Chao Wen Huan Chen Yunbing Tang Hang Lin Congcong Xu Yingfen Ying Yang Zhu Xinjun Miao Ren-Shan Ge Chao Chen Shangqin Chen Source Type: research