Safety of non-ionic contrast media in CT examinations for out-patients: retrospective multicenter analysis of 473,482 patients

ConclusionThe use of NICM for out-patients is in general safe with a low ADR incidence. The type of contrast medium (iopromide) and the seasons (summer and autumn) were associated with a higher risk of acute ADRs. Late ADRs were more often observed with iodixanol.Clinical relevance statementIn comparison to in-patients, out-patients may be exposed to higher risk due to a lack of extensive risk screening, less nursing care, and higher throughput pressure. Safety data about NICM from a large population may complement guidelines and avoid ambiguity.Key Points•The incidence and risk factors for adverse events after using non-ionic iodinated contrast media are complex in out-patients.•Non-ionic iodinated contrast media are safe for out-patients and the overall incidence of adverse drug reactions was 0.110%.•There is a higher risk of acute adverse drug reactions in summer and autumn.
Source: European Radiology - Category: Radiology Source Type: research