PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection

In this study, we identify PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in an almost complete ablation of both Tfh and T follicular regulatory populations and, consequently, reduced B cell activation and influenza-specific Ab production. Supporting a potential mechanism, we observe elevated surface expression of IL-2Rα on non-T regulatory effector PRMT5-deficient T cells. Notably, IL-2 signaling is known to negatively impact Tfh differentiation. Collectively, our findings identify PRMT5 as a prominent regulator of Tfh programming, with potential causal links to IL-2 signaling.PMID:38436421 | DOI:10.4049/jimmunol.2300270

Source: Journal of Immunology - March 4, 2024 Category: Allergy & Immunology Authors: Kaitlin A Read Stephanie A Amici Sadaf Farsi Madeline Cutcliffe Bella Lee Chan-Wang Jerry Lio Hsin-Jung Joyce Wu Mireia Guerau-de-Arellano Kenneth J Oestreich Source Type: research