The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function

Nine genes that potentially enhance the risk of Alzheimer disease (AD) were identified using a novel gene-constrained analytical method. One gene encoded heterotrimeric G protein beta family member GNB5. In AD model mice, Gnb5 heterozygosity enhanced the development of AD neuropathology. This method may be applicable to other polygenic diseases.

Source: The American Journal of Human Genetics - February 13, 2024 Category: Genetics & Stem Cells Authors: Jianhua Zhang, Mritunjay Pandey, Adam Awe, Nicole Lue, Claire Kittock, Emma Fikse, Katherine Degner, Jenna Staples, Neha Mokhasi, Weiping Chen, Yanqin Yang, Poorni Adikaram, Nirmal Jacob, Emily Greenfest-Allen, Rachel Thomas, Laura Bomeny, Yajun Zhang, Ti Tags: Article Source Type: research