CLU (clusterin) and PPARGC1A/PGC1 α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival

In conclusion, CLU and PPARGC1A are essential for sustained cancer cell growth by activating mitophagy and mitochondrial biogenesis, respectively, and their inhibition could provide better therapeutic benefits against oral cancer.PMID:38447939 | DOI:10.1080/15548627.2024.2309904

Source: Autophagy - March 6, 2024 Category: Cytology Authors: Prakash P Praharaj Srimanta Patra Amruta Singh Debasna P Panigrahi Hwa Y Lee Mohammad F Kabir Muhammad K Hossain Samir K Patra Birija S Patro Shankargouda Patil Daniel J Klionsky Han J Chae Sujit K Bhutia Source Type: research