Circumventing aglycon transfer en route to the synthesis of pentasaccharide thioglycoside donor for the chain extension of Plesiomonas shigelloides strain 302-73 (serotype O1) repeating unit

Carbohydr Res. 2024 Mar 1;537:109073. doi: 10.1016/j.carres.2024.109073. Online ahead of print.ABSTRACTHerein we report a chemical synthesis of a pentasaccharide thioglycoside repeating unit of Plesiomonas shigelloides Strain 302-73 (Serotype O1), as a chain extension unit. In our synthetic endeavor we encountered multiple aglycon transfer reactions during glycosylations. This problem was obviated by employing a PMP group as a transient protecting group.PMID:38442682 | DOI:10.1016/j.carres.2024.109073
Source: Carbohydrate Research - Category: Genetics & Stem Cells Authors: Source Type: research