Preliminary report on therapeutic potential of coal-derived carbon quantum dots against SARS-CoV-2 virus

Virology. 2024 Feb 27;593:110036. doi: 10.1016/j.virol.2024.110036. Online ahead of print.ABSTRACTDue to the pandemic of COVID-19 and subsequent emerging of new mutant strains, there has been a worldwide hunt for therapeutic and protective agents for its inhibition. In this short communication, for the first time, we report the coal-derived carbon quantum dot (CQD) for the possible therapeutic application against SARS-CoV-2. The synthesized C1-CQD is observed to be safe towards the normal cell line at highest dose, while effectively inhibiting growth of SARS-CoV2 (>95%) with IC50 value of 5.469 μg/mL. Moreover, C1-CQD showed activity against SARS-CoV-2 infection which is comparable to known inhibitory antiviral drug i.e., Remdesivir. These novel findings indicate that coal-based CQDs have highly potent anti-viral activity and could be investigated further for developing cheap and safer alternative therapeutic strategies for inhibition of SARS-CoV-2.PMID:38432047 | DOI:10.1016/j.virol.2024.110036

Source: Virology - March 3, 2024 Category: Virology Authors: Binoy K Saikia Kallol Roy Rituraj Konwar Source Type: research