Overexpression of ETV2 in BMSCs promoted wound healing in cutaneous wound mice by triggering the differentiation of BMSCs into endothelial cells and modulating the transformation of M1 phenotype macrophages to M2 phenotype macrophages

In conclusion, this study revealed a novel biofunction of ETV2 molecule in the wound healing process. ETV2 overexpression in BMSCs promoted wound healing in CW mice by triggering BMSCs differentiation into endothelial cells and modulating the transformation of M1 pro-inflammatory and M2 anti-inflammatory macrophages in vitro and in vivo.PMID:38430850 | DOI:10.1016/j.tice.2024.102334

Source: Tissue and Cell - March 2, 2024 Category: Cytology Authors: Xiuchao Shang Yesheng Jin Yuan Xue Xiaoyun Pan Haiquan Zhu Xiangsheng Meng Zhihai Cao Yongjun Rui Source Type: research