The free plasma amyloid A β < sub > 1-42 < /sub > /A β < sub > 1-40 < /sub > ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma A β < sub > 1-42 < /sub > /A β < sub > 1-40 < /sub > ratio. The BALTAZAR study

CONCLUSION: The free plasma Aβ1-42/Aβ1-40 ratio is associated with a risk of conversion from MCI to dementia within three years, with performance comparable to that of the total plasma Aβ1-42/Aβ1-40 ratio. Threshold levels of the free and total plasma Aβ1-42/Aβ1-40 ratio could be determined, with a 60% lower risk of conversion for patients above the threshold than those below.PMID:38423192 | DOI:10.1016/j.nbd.2024.106459

Source: Neurobiology of Disease - February 29, 2024 Category: Neurology Authors: S Schraen-Maschke A Duhamel J S Vidal N Ramdane L Vaudran C Dussart L Bu ée B Sablonni ère C Delaby B Allinquant A Gabelle S Bombois S Lehmann O Hanon BALTAZAR study group Source Type: research