Characterization and mitigation of artifacts derived from NGS library preparation due to structure-specific sequences in the human genome

Hybridization capture-based targeted next generation sequencing (NGS) is gaining importance in routine cancer clinical practice. DNA library preparation is a fundamental step to produce high-quality sequencing...

Source: BMC Genomics - March 1, 2024 Category: Genetics & Stem Cells Authors: HuiJuan Chen, YiRan Zhang, Bing Wang, Rui Liao, XiaoHong Duan, ChunYan Yang, Jing Chen, YanTong Hao, YingShuang Shu, LiLi Cai, Xue Leng, Nian-Song Qian, DaWei Sun, Beifang Niu and Qiming Zhou Tags: Research Source Type: research