MicroRNA-7 Attenuates Secondary Brain Injury Following Experimental Intracerebral Hemorrhage via Inhibition of NLRP3

Intracerebral hemorrhage (ICH), a prevalent condition in neurosurgery, constitutes approximately 10-15% of all stroke types. Its global annual incidence surpasses 200 million cases, and the associated high disability and mortality rates pose substantial burdens on families and society.1 Presently, the mechanisms driving brain damage in ICH remain incompletely deciphered, and adequate medical interventions to enhance patient prognosis are yet to be established. Mechanisms of brain tissue damage following ICH include hematoma mass effect, excitotoxicity, oxidative stress, and inflammatory reactions.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research