A novel lncRNA TCONS_00071187 upregulated by activated GSK3 β promotes high glucose-induced mesangial cell proliferation in the diabetic nephropathy

In conclusion, GSK3β promoted mesangial cell proliferation by upregulating TCONS_00071187, which led to enhanced ROS production under high glucose conditions in the cell model of DN. This study revealed the role of GSK3β medicated lncRNAs in the development of DN.PMID:38372092 | DOI:10.14715/cmb/2024.70.1.30

Source: Cellular and Molecular Biology - February 19, 2024 Category: Molecular Biology Authors: Zhaoshou Yang Xiaoxiao Sun Xiaofeng Deng Wengong Jiang Zhihao Zhang HaiBo Liu Mengdan Zhong Yanfeng Xie Yongdui Ruan Hongmei Lu Source Type: research