Methylmercury-induced brain neuronal death in CHOP-knockout mice

In this study, to clarify whether CHOP mediates MeHg-induced apoptosis, we examined the effect of CHOP deletion on MeHg exposure in CHOP-knockout mice. Our data showed that CHOP deletion had no effect on MeHg exposure-induced weight loss or hindlimb impairment in mice, nor did it increase apoptosis or inhibit neuronal cell loss. Hence, CHOP plays little role in MeHg toxicity, and other apoptotic pathways coupled with ER stress may be involved in MeHg-induced cell death.PMID:38296529 | DOI:10.2131/jts.49.55
Source: Journal of Toxicological Sciences - Category: Toxicology Authors: Source Type: research