Antioxidant, cytotoxic, anti-glycation, and anti-tyrosinase compounds from the leaves of Uvaria siamensis

Chem Biodivers. 2024 Feb 29:e202400319. doi: 10.1002/cbdv.202400319. Online ahead of print.ABSTRACTA new oxidized heptene, 7-benzoyloxy-4-hydroxy-1-ethoxy-2E,4Z-heptadiene-1,6-dione, namely siamheptene A (1), together with eight known compounds (2-9), were isolated from the leaves of Uvaria siamensis. Their structures were identified by detailed analysis of spectroscopic (IR, 1D and 2D NMR) and mass spectrometric data. Compound 9 is reported for the first time from Uvaria genus. Siamheptene A was evaluated for cytotoxicity against HeLa (cervical cancer cells), A549 (lung cancer cells), and Vero cells using the MTT assay and screened for antibacterial activities. In addition, isolated compounds (1-7, and 9) were investigated for their antioxidant (DPPH, FRAP and ABTS assays), anti-glycation, and anti-tyrosinase properties. Based on our results,compound 1 had mild cytotoxicity against Hela and A549 cancer cell lines, with IC50 ranging from 31.09 to 31.67 μg/mL. Compound 1 also showed antioxidant activities in all tasted assays. However, it showed no detectable activity (> 128 μg/mL) against various bacterial strains, and it has no inhibitory effects on tyrosinase enzymes. Among of all tested compounds, chrysin (5), showcased highest anti-glycation and anti-tyrosinase activities. This comprehensive analysis provides highlighting the potential of 1 as a lead compound for further structural modification and development of cytotoxic or antioxidant agents.PMID:38423999 | DOI:10...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Source Type: research