The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer ’s disease model mice and its mechanism

ConclusionsCeramide was positively related to the increased p-tau and impaired cognitive function. The increased generation of ceramide and endoplasmic reticulum stress in the hypothalamus was positively related to fatty acid synthesis and NF- κB signaling via brain–liver axis.
Source: Psychopharmacology - Category: Psychiatry Source Type: research