Recombinant IGF-1/BP3 protects against intestinal injury in a neonatal mouse NEC model

CONCLUSIONS: Exogenous rhIGF-1/BP3 protects neonatal mice against experimental NEC via multiple mechanisms.IMPACT: Exogenous rhIGF-1/BP3 preserves intestinal microvascular development and integrity, promotes enterocyte proliferation and migration, decreases local and systemic inflammation, and protects neonatal mice against NEC. The article adds pre-clinical evidence of a protective role for rhIGF-1/BP3 on the premature gut. It provides evidence supporting the use of rhIGF1/BP3 in premature neonates to protect against NEC.PMID:38418592 | DOI:10.1038/s41390-024-03069-8

Source: Pediatric Research - February 28, 2024 Category: Pediatrics Authors: Xiaocai Yan Elizabeth Managlia Galen Carey Norman Barton Xiao-Di Tan Isabelle G De Plaen Source Type: research